• Human Pyruvate Dehydrogenase E1 Component
• References
• Protein Monogram
• Slides

Works Cited:

1) Whitley, M., et al., 2018. Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the ?V138M variant of human pyruvate dehydrogenase. The Journal of Biological Chemistry 293: 13204-13213. 

2) Protein Data Bank. https://www.rcsb.org/structure/6CFO 

3) Kato, M., et al., 2008. Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. Structure 16, 1849-1859. 

4) Protein identification and analysis tools on the ExPASy server. Gasteiger, E. et. al. In J. M. Walker (Ed.) The proteomics protocols handbook. Totowa, New Jersey: Humana Press Inc. 2005. 

5) Seifert, F., et al., 2007. Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex. Biochemistry 46, 6277-6287. 

6) Basic Local Alignment Search Tool. National Center for Biotechnology Information. 2012. http://www.ncbi.nlm.nih.gov/blast/Blast.cgi 

7) Frank, R., et al., 2007. Crystal Structure of the E1 Component of the Escherichia coli 2-Oxoglutarate Dehydrogenase Multienzyme Complex. The Journal of Biological Chemistry 368, 639-651. 

8) Protein Data Bank. https://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=2JGD 

9) Dali server: conservation mapping in 3D. Nucl. Acids Res. 38, W545-549. Holm L, Rosenström, P. 2010.